A team of six hospital staff ran the Derby 10K while pushing a 70kg (154lb) dialysis machine.
The old machine, nicknamed "Dougie", was used at Sunday's event to raise awareness of kidney failure and to help fund a new caravan in North Wales for dialysis patients.
The Royal Derby Hospital's renal dialysis unit is fundraising to replace the caravan, which allows patients to continue dialysis while on holiday.
Chris Swan, 45, a member of the team who took part in the event, said: "It took us one hour and a minute, which was quite surprising. Dougie wanted to go quicker, I think, so he pulled us along."
Mr Swan, a home therapies trainer, who has worked in the unit for more than 30 years, added: "When it was really warm in the sun, it was quite gruelling, but it was worthwhile.
"The crowd really pushed us on and gave us the support. Before we knew it, it was over."
Dialysis is a procedure to remove waste products and excess fluid from the blood when the kidneys stop working properly.
The group are raising money for Derby and Burton Hospitals Charity, which also funds the current caravan.
They are aiming to raise between £60,000 and £80,000 for the new caravan, which they hope will be ready to use in 2026.